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Drug Interactions of Caralluma fimbriata:
No evidence of any drug interactions was found for
Caralluma fimbriata, its taxonomic synonyms. However, it
is theoretically possible that if the concentration of
luteolin-4?-O-neohesperidoside in a preparation of the
plant1,10 was sufficiently high and had sufficient
bioavailability, it could have additive effects when
taken with anti-inflammatory or analgesic medications.
The concentration of the flavone glycoside in a methanol
extract of the whole fresh plant (0.5%) was much greater
than levels found in extracts of two related species of
Caralluma collected in India (0.01% in Caralluma
lasiantha and 0.001% in Caralluma umbellata).10 Based on
animal studies,1 anti-inflammatory effects might be
achieved from ingestion of Caralluma fimbriata if the
dose was sufficiently high (approx. 32-64 grams) or if
an extract preparation was sufficiently concentrated,
whereas analgesic effects might only be achieved from
doses 6 times that of an anti-inflammatory dose.
Safety Statement of Caralluma fimbriata:
Considering the history of Caralluma fimbriata as a
traditional food in India, there is a presumption of
short- and long-term safety, particularly with no
evidence from the historical, empirical record nor from
modern pharmacological/toxicological testing to suggest
otherwise. Thus, Caralluma fimbriata dietary supplement
preparations are considered relatively safe when used
appropriately.
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